In the United States, skin wounds affect 6.5 million patients placing a major burden, estimated at US$25 billion annually, on society. The research program at OSU utilizes novel state of the art molecular technologies to understand mechanisms that impair healing of chronic wounds. Understanding the mechanisms of action of specific therapeutic intervention is another active area of investigation. A strong multidisciplinary team consisting of clinicians, molecular biologists, imaging specialists, biomedical engineers, statisticians and system biologists support the research program. There is a continuum from bench to bedside and back. The studies are performed in cell culture, rodent, preclinical and clinical systems.
i) diabetic wound healing
ii) miRNA therapeutics, wound inflammation and angiogenesis,
iii) redox and oxygen biology,
iv) non-invasive wound imaging,
v) biofilm, infection and therapeutics,
vi) wound genomics (microarray), proteomics and laser capture microdissection (LCM).