Scott Schricker, PhD
Division of Restorative, Prosthetic and Primary Care, College of Dentistry
Phone number: (614) 688-3367
We are developing nanostructured biomaterial surfaces composed of block copolymers capable of modulating the adhesion and conformation of adsorbed proteins with the ultimate goal of optimizing cellular adhesion and behavior. The biomaterial-cell interface is governed by the types and conformations of proteins deposited on the biomaterials surface upon implantation. The protein behavior is in turn governed by the morphology and chemistry of the biomaterial surface. Block copolymers generate a diversity of nanostructured surfaces by manipulating the blocks of known biocompatible polymers. This tunability of the block copolymer surface morphology can be exploited to control stem cell differentiation in the development of novel cell-based therapies.
In this project, we are collaborating with Prof. Bharat Bhushan at the Department of Mechanical and Aerospace Engineering, whose group has significant expertise on advanced AFM techniques as applied to the study of nanomorphology and nanomechanical properties of biomaterials and biomolecules.
Wan Q, Rumpf D, Schricker SR, Mariotti A, Culbertson BM. Influence of hyperbranched multi-methacrylates for dental neat resins on proliferation of human gingival fibroblasts. Biomacromolecules. 2001: 2: 217-222.
Skaria S, Schricker SR. Synthesis and Characterization of Inorganic-Organic Hybrid Materials Derived from Polysilsesquioxanes (POSS). J Macromol Sci, Part A: Pure Appl Chem. 2010: 47: 381–391.
Schricker S, Palacio M, Thirumamagal BTS, Bhushan B. Synthesis and morphological characterization of block copolymers for improved biomaterials. Ultramicroscopy. 2010: 110: 639-649.
Palacio M, Schricker S, Bhushan B. Morphology and protein adsorption characteristics of block copolymer surfaces. J. Microsc. 2011: 240: 239-248.
Schricker S, Palacio M, Bhushan B. “Protein adhesion of block copolymer surfaces.” Colloid Polym. Sci. 2011: 289: 219-225.
Palacio M, Schricker S, Bhushan B. “Bioadhesion of various proteins on random, diblock and triblock copolymer surfaces and the effect of pH conditions,” J. R. Soc. Interface. 2011: 8: 630-640.
Schricker S, Palacio M, Bhushan B. Antibody sensed protein surface conformation. Materials Today. 2011: 14: 616-621.
Palacio M, Schricker S, Bhushan B. Block copolymer arrangement and composition effects on protein conformation using atomic force microscope-based antigen-antibody adhesion. J. Biomed. Mater. Res. A. 2012: in press.