Jed Johnson, PhD
Phone: (614) 453-5877
Nanofiber Solutions (NFS) develops and markets electrospun nanofiber scaffolds for cell culture, drug development, and tissue engineering applications including the first in man synthetic nanofiber trachea. We offer a variety of configurations ranging from multiwell culture plates to larger commercial bioreactor configurations to custom designed tissue scaffolds. Historically, cell culture has been performed on flat, tissue culture polystyrene (TCPS) because it is cheap, optically clear, and many cells grow well on it. In reality, however, living organisms are made up of an extracellular matrix (ECM) that presents both aligned physical structure and mechanical support to the cells. Adherent cells are complex, self-sustaining units that require ECM anchorage to proliferate and undergo normal differential function. Nanofiber Solutions seeks strategic partners well established in tissue engineering and medical implants to help us bring other applications of this platform technology to market. Other applications include small and large diameter blood vessels, esophagus, colon, intestine, cartilage, wound healing and hernia repair.
Synthetic scaffolds and implants for tissue engineering
Bioreactor-based stem cell expansion
High-throughput drug discovery
Cell based assays
Johnson, J.; Ghosh, A.; Lannutti, J., Microstructure-Property Relationships in a Tissue Engineering Scaffold. Journal of Applied Polymer Science 2007, 104, 2919-2927.
Johnson, J., Niehaus, A., Nichols, S., Lee, D., Koepsel, J., Anderson, D., and Lannutti, J. Electrospun PCL In Vitro: A Microstructural Basis for Mechanical Property Changes. Journal of Biomaterials Science 2009, 20, (4), 467-481.
Veleva, A., Heath, D., Johnson, J., Nam, J., Patterson, C., Lannutti, J., Cooper, S. Interactions between Endothelial Cells and Electrospun Methacrylic Terpolymer Fibers for Engineered Vascular Replacements. Journal of Biomedical Materials Research Part A 2009, 91A, (4), 1131-1139.
Johnson, J. K.; Nowicki, O. M.; Lee, C. H.; Chiocca, A. E.; Viapiano, M. S.; Lawler, S. E.; Lannutti, J. J., Quantitative analysis of complex glioma cell migration on electrospun polycaprolactone using time-lapse microscopy. Tissue Engineering Part C: Methods 2009, 15(4): 531-540.
Lim, Y., Johnson, J., Fei, Z., Wu, Y., Farson, D., Lannutti, J., Choi, H., Lee, L. Micropatterning and Characterization of Electrospun Poly(ε-Caprolactone)/Gelatin Nanofiber Tissue Scaffolds by Femtosecond Laser Ablation for Tissue Engineering Applications. Biotechnology and Bioengineering 2011, 108, (1), 116-126.
Fischer, S., Johnson, J., Baran, C., Newland, C., Marsh, C., Lannutti, J. Organ-derived coatings on electrospun nanofibers as ex vivo microenvironments. Biomaterials 32 (2011) 538-546.
Nam, J. Johnson, J. Lannutti, J. Agarwal, S. Modulation of embryonic mesenchymal progenitor cell differentiation via control over pure mechanical modulus in electrospun nanofibers. Acta Biomaterialia 7 (2011): 1516-1524.
Han, N., Rao, S., Johnson, J., Parikh, K., Bradley, P., Lannutti, J., Winter, J. Hydrogel-electrospun fiber mat composite coatings for neural prostheses. Frontiers in Neuroengineering 4 (2011): 1-8.
Agudelo-Garcia, P., De Jesus, J., Williams, S., Nowicki, M., Chiocca, E., Liyanarachchi, S., Li, P., Lannutti, J., Johnson, J., Lawler, S., Viapiano, M. Glioma cell migration on 3D nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling. Neoplasia 2011, 13(9): 831-840.
Han, N., Johnson, J., Bradley, P., Parikh, K., Lannutti, J., Winter, J. Cell Attachment to Hydrogel-Electrospun Fiber Mat Composite Materials. Accepted at Journal of Functional Biomaterials.