Michael J. Miller, MD,
Professor of Surgery, Chair, Department of Plastic Surgery
Phone: (614) 293-9885
The objective of this project is to apply topological optimization methods to create feasible bone replacement forms for large segmental defects in craniofacial reconstruction. Restoring normal function and appearance after massive facial injuries due to blast or tumor removal with bone loss still remains an important unresolved problem in craniofacial reconstruction surgery. The current methods are heuristic in nature and ad hoc design of bone replacements is done by the operating surgeon at the time of surgery. Within a given space defined by the wound, bone replacements have to be designed to meet structural functions, to maintain permanently a specific three-dimensional shape, and to support soft tissues and prosthetic appliances. A multi-level topological optimized method will be applied and tailored to create new bone replacement forms that not only meet requirements for load-bearing, but also position tissue elements in the proper locations in space to support soft tissues and prosthetic appliances. The integration of the replacement forms in the deformity regions and validation of the feasibility of using the tailored craniofacial design shapes will be carried out. The research project is a synergy of tissue engineering research, clinical surgery and computational mechanics.
Bone Tissue Engineering
Tissue Engineered Bone Flaps in Sheep
Injectable Biomaterials of Tissue Engineering
Stem Cell Plasticity and Tissue Repair
Reconstruction of Bone Defects Using Periosteum and Regenerative Biomaterials,
Craniofacial Reconstruction using Engineering Techniques
Guided Bone Formation
Principal Investigator, Topological Optimization Methods for Designing Patient-Specific Large Craniofacial Segmental Bone Replacements, National Science Foundation, ends 5/1/10 - 4/30/12, $158,407
Co-Investigator, Reconstruction of Bone Defects Using Periosteum and Regenerative Biomaterials, Musculoskeletal Transplant Foundation, PI: Anshu B. Mathur, Ph.D., 01/01/2006-12/31/2006,
Co-Investigator, Stem Cell Plasticity and Tissue Repair, UT M.D. Anderson Cancer Center Multidiscipline Research Project, PI: Zeev Estrov, MD, 2003-2006
Principal Investigator, Assessment of capillary density and osteoblast viability within the minimal essential unit of a tissue fabrication device, IRG Grant – The University of Texas, M. D. Anderson Cancer Center, 2000-2001
Principal Investigator, Bone Regeneration by Osteoblast Transplantation, National Institute of Diabetes and Digestive and Kidney Disease Student Summer Research Program (NIDDK), 5/30/2000-8/4/2000
Co-Investigator, Evaluation of Endosseous Implants in guided-growth microvascular bone flaps in a sheep model The Osseointegration Foundation, Principal Investigator: Jacob RF, 1997-1998
Consultant, Bone Regeneration by Osteoblast Transplantation, NIH Grant R29, Principal Investigator: Mikos A, 1996-2001, $504,070 ($100,814/year)
Consultant, Injectable Biomaterials of Bone Tissue Engineering, NIH Grant 1 R01 AR44381-01, Principal Investigator: Mikos A, 1996-2001 $1,018,445 ($203,689/year)
Principal Investigator, Industrial funding for cooperative efforts for development of minimally invasive tissue harvest techniques, Ethicon Endo-Surgery, Inc., Research Foundation Fund, 1992-1996
Principal Investigator, Calvarial Defect Reconstruction Using Cultured Osteoblast/Polymer Constructs, Research Funds Competition for Clinical Trainees, 1996
Principal Investigator, Tissue Engineered Bone Flaps in Sheep, The University of Texas M.D. Anderson Cancer Center, PRS Grant ECRA, 1995-1996
Co-Investigator, r-Human Bone Morphogenic Protein-2 as Bone Graft Substitute for Bone Defects, The University of Texas M.D. Anderson Cancer Center, PRS
Principal Investigator, Tissue Engineering Strategies for Bone, The Irene Cafcalas Hofheinz Foundation, 1995
Principal Investigator, Reconstruction of Bone Tissue and Devising New Ways to Control and Direct Bone Growth, The Irene Cafcalas Hofheinz Foundation, 1993-1995
A. Sutradhar, G. H. Paulino, MJ Miller, T. Nguyen. “Topological optimization for designing large craniofacial segmental bone replacement”, Proceedings of the National Academy of Sciences (PNAS), 107(30):13222-
Rios CN, Skoracki RJ, Miller MJ, Satterfield WC, Mathur AB. In vivo bone Formation in silk fibroin and chitosan blend scaffolds via ectopically grafted Periosteum as a cell source: a pilot study. Tissue Engineering, Part A 15(9):2717,2009.
Cheng MH, Brey EM, Allori AC, Gassman A, Chang DW, Patrick CW Jr, Miller MJ. Periosteum-guided prefabrication of vascularized bone of clinical shape and Volume. Plast Reconstr Surg 124(3):787, 2009.
Brey EM, Cheng MH, Allori A, Satterfield W, Chang DW, Patrick CW Jr, Miller MJ. Comparison of guided bone formation from periosteum and muscle fascia. Plast Reconstr Surg 119(4):1216-22, 2007.
Hedberg EL, Kroese-Deutman HC, Shis CK, Lemoine JJ, Liebcshner MAK, Miller MJ, Yasko AW, Crowther RS, Carney DH, Mikos AG, Jansen JA. Methods: A comparative analysis of radiography, micro-computed tomography, and histology for bone tissue engineering. Tissue Eng, 11(9/10):1356-1367, 2005.
Cheng MH, Brey EM, Allori A, Satterfield WC, Chang DW, Patrick CW Jr, Miller MJ. Ovine model for engineering bone segments. Tissue Eng 11(1-2):214-225, 2005.
Miller MJ. Osseous tissue engineering in oncologic surgery. Semi Surg Oncol 19(3):294-301, 2000.
Peter SJ, Miller MJ, Yasko AW, Yaszemski MJ, Mikos AG. Review: Polymer concepts in tissue engineering. J Biomed Mater Res 43(4):422-427, 1998.
Ishaug SL, Crane GM, Miller MJ, Yasko AW, Yaszemski MJ, Mikos AG. Bone formation by three-dimensional stromal osteoblast culture in biodegradable polymer scaffolds. J Biomed Materials Res 36(1):17-28, 1997.
Miller MJ, Goldberg D, Yasko AW, Lemon JC, Satterfield W, Wake MC, Mikos AG. Guided bone growth in sheep: A model for tissue-engineered bone flaps. Tissue Engineering 2(1):51-59, 1996