Gregg Allen Hadley, PhD
Professor, Department of Surgery
Director, Tissue Typing Laboratory
Deputy Director of Research, Comprehensive Transplant Center
Phone number: (614) 247-6006
As of 2005, an estimated 1.4 - 2.8 million people in the United States were diagnosed with insulin dependent diabetes (www.citregistry.org
). According to a 2007 report by the United Network for Organ Sharing (UNOS), only 1,931 pancreatic donors were reported, of which the vast majority (1,363) were used for whole pancreas transplantation with only 568 pancreata available for islet transplantation. In addition to the already limited supply of pancreata for islet transplantation, most islet transplant recipients require more than one donor in order to acquire a sufficient number of islet cells to achieve insulin independence. It is known that both auto- and allogeneic immune responses severely limit the long-term success of islet grafts, even when an abundant number of islets have been transplanted. The overall goal of this multidisciplinary research team is to: 1) Develop immunosuppressive treatment strategies that protect islets from long-term immune injury, and 2) Pioneer the transplantation of pig islets into human diabetics to assure an adequate supply of donor tissue. These areas of interest have obvious relevance to the new center and efforts will be made to emphasize the common goals.
Christopher Adin, DVM, Associate Professor, Department of Veterinary Clinical Sciences
Tracey Papenfuss, DVM, PhD, Assistant Professor, Departments of Veterinary Medicine and Pulm,Allergy,Crit Care & Sleep
Amer Rajab, MD, PhD, Associate Professor, Department of Surgery
Kwame Osei, M.B., Ch B., Professor, Departments of Medicine and Exercise Physiology
Douglas McCarty, PhD, Principle Investigator, Center for Gene Therapy Neuromuscular Disorders, Nationwide Children's Hospital
Stephen C. Lee, PhD, Associate Professor, Department of Biomedical Engineering
Transplantation of pancreatic islets to cure type I diabetes
Buss, J., E. Essig, K. Osei, S. Brodsky, G. Hadley, and A. Rajab. 2011. Steroid-free maintenance of islet allografts using mycophenolate mofetil and cyclosporine in the non-human primate. Ann Transplant 16:88-97.
Rajab A, Buss J, Diakoff E, Hadley GA, Osei K, and Ferguson RM. 2008. Comparison of the portal vein and kidney subcapsule as sites for primate islet autotransplantation. Cell Transplantation. no. 17 (2008): 1015-1023.
Feng Y, Wang D, Yuan R, Parker CM, Farber, DL, and Hadley GA. CD103 expression is required for destruction of pancreatic islet allografts by CD8+ T cells. J. Exp. Med 196:877-886, 2002.
Liu K, Anthony BA, Yearsly MM, Hamadani M, Gaughan A, Wang JJ, Devine SM, and Hadley GA. CD103 deficiency prevents graft-versus-host disease but spares graft-versus-tumor effects mediated by alloreactive CD8 T cells. PLoS One 2011; 6 (7): e21968.
Zhang L, Moffatt-Bruce S, Gaughan A, Wang J, Rajab A, and Hadley GA. Depletion of CD103 expressing cells promotes long term survival of pancreatic islet allografts. Am J Transplant 9:2012, 2009.
El-Asady R, Yuan R, Liu K, Gress RE, Lucas PJ, Drachenberg CI, and Hadley GA. TGF-b-dependent CD103 expression by CD8+ T cells promotes selective destruction of the host intestinal epithelium during graft-vs-host disease. J. Exp. Med 201:1647-1657, 2005.
Yuan R, Drachenberg CI, and Hadley GA. Critical role for CD103+CD8+ effectors in promoting tubular injury following allogeneic renal transplantation. J. Immunol. 175:2868-2879, 2005.
Anthony, BA, and GA Hadley. Induction of graft-versus-host disease and in vivo T cell monitoring using an MHC-matched murine model. Journal of Visualized Experiments (In press).
Fu, H., J. Dirosario, S. Killedar, K. Zaraspe, and D.M. McCarty. 2011. Correction of neurological disease of mucopolysaccharidosis IIIB in adult mice by rAAV9 trans-blood-brain barrier gene delivery. Mol Ther 19:1025-1033.
Papenfuss, T.L., N.D. Powell, M.A. McClain, A. Bedarf, A. Singh, I.E. Gienapp, T. Shawler, and C.C. Whitacre. 2011. Estriol generates tolerogenic dendritic cells in vivo that protect against autoimmunity. J Immunol 186:3346-3355.