Hyperbaric oxygenation and myocardial pO2 in the infarct heart. Myocardial pO2 in the infarct rat hearts were measured before (normoxia) and after hyperbaric oxygenation (100% O2 at 2 ATA for 90 min using a custom-built small-animal chamber. Data represent mean±SD obtained from 4 rats. The results show an increase in oxygenation levels reaching significance at 90 min followed by returning to baseline in about 2 hours in the infarct hearts. A 5.8-fold increase in oxygenation was achieved in the infarct hearts after 90 min of HBO. (Adapted from Khan et al. J Mol Cell Cardiol 47, 275-287, 2009).
Myocardial pO2 in rat hearts transplanted with bone marrow-derived rat mesenchymal stem cells (MSC) at 2 weeks. The results (mean±SD; N=6 rats) show an increase in myocardial oxygenation in hearts treated with MSC and further enhancement in pO2 was observed in hearts treated with HBO (100% O2, 2ATA, 90 min/day for 10 days).