Cameron L. Rink, PhD
Assistant Professor, Surgery
Phone number:
Email:
cameron.rink@osumc.edu/614-366-3806
The central focus of the Rink laboratory is to understand neural and cerebrovascular adaptations that protect the brain from ischemic stroke injury. These adaptations include the formation and recruitment of collateral blood supply to improve perfusion at the stroke-affected site, and mechanisms of post-stroke neuroplasticity that facilitate recovery from stroke-induced loss of motor function. Pro-arteriogenic factors (TIMP1, CLIC1, CLIC4) are the mechanistic focus in studies addressing cerebrovascular collaterals, while the family of neurotrophins are currently being investigated for their role in neuroplasticity and post-stroke functional recovery in conjunction with mechanical therapy. The laboratory employs pre-clinical stroke models (small and large animal) to study nutritional and mechanical interventions against stroke. Technology platforms used by the lab include magnetic resonance imaging (T2 weighted imaging and DTI-based tractography), laser speckle flowmetry, laser capture microdissection (LCM), corrosion cast with scanning electron microscopy (SEM), and software-assisted sensorimotor testing.
Savita Khanna PhD, Assistant Professor (collaborator)
Chandan K. Sen PhD, Professor (collaborator)
Sashwati Roy PhD, Associate Professor (collaborator)
Gayle Gordillo MD, Associate Professor (collaborator)
Andrew Slivka MD, Professor (collaborator)
Mallory Heigel BS, Research Assistant
Cerebrovascular disease, stroke, nutrition, neuroplasticity
Rink C, Christoforidis G, Khanna S, Peterson L, Patel Y, Khanna S, Abduljalil A, Irfanoglu O, Machiraju R, Bergdall VK, Sen CK. Tocotrienol vitamin E protects against preclinical canine ischemic stroke by inducing arteriogenesis. J Cereb Blood Flow Metab. 2011 Nov;31(11):2218-30. PMID:21673716
Rink C, Gnyawali S, Peterson L, Khanna S. Oxygen-inducible glutamate oxaloacetate transaminase as protective switch transforming neurotoxic glutamate to metabolic fuel during acute ischemic stroke. Antioxidants & Redox Signaling 14: 1777-85, 2011. PMCID: PMC3078502
Rink C, Roy S, Khan M, Ananth P, Kuppusamy P, Sen CK, Khanna S. Oxygen-sensitive outcomes and gene expression in acute ischemic stroke. Journal of Cerebral Blood Flow and Metabolism 30: 1275-87, 2010. PMCID: PMC2913550
Rink C, Christoforidis G, Abduljalil A, Kontzialis M, Bergdall V, Roy S, Khanna S, Slivka A, Knopp M, Sen CK. Minimally invasive neuroradiologic model of preclinical transient middle cerebral artery occlusion in canines. Proc Natl Acad Sci U S A 105: 14100-5, 2008. PMCID: PMC2544585
Rink C, Khanna S. MicroRNA in ischemic stroke etiology and pathology. Physiological Genomics 43: 521-8, 2011. PMID: 20841499
Rink C, Khanna S. Significance of brain tissue oxygenation and the arachidonic acid cascade in stroke. Antioxidants & Redox Signaling 14: 1889-903, 2011. PMCID: PMC3078506
Rink C, Roy S, Khanna S, Rink T, Bagchi D, Sen CK. Transcriptome of the subcutaneous adipose tissue in response to oral supplementation of type 2 Leprdb obese diabetic mice with niacin-bound chromium. Physiological Genomics 27: 370-9, 2006.
